Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds
Wang, Kai-Ling1,2; Xu, Ying2,4; Lu, Liang3; Li, Yongxin2; Han, Zhuang2,5; Zhang, Jun6; Shao, Chang-Lun1; Wang, Chang-Yun1; Qian, Pei-Yuan2,3
2015-10-01
Source PublicationMARINE BIOTECHNOLOGY
Volume17Issue:5Pages:624-632
AbstractIn the present study, eight natural products that belonged to di(1H-indol-3-yl)methane (DIM) family were isolated from Pseudovibrio denitrificans UST4-50 and tested for their antifouling activity against larval settlement (including both attachment and metamorphosis) of the barnacle Balanus (=Amphibalanus) amphitrite and the bryozoan Bugula neritina. All diindol-3-ylmethanes (DIMs) showed moderate to strong inhibitory effects against larval settlement of B. amphitrite with EC50 values ranging from 18.57 to 1.86 mu M and could be considered as low-toxicity antifouling compounds since their LC50/EC50 ratios were larger than 15. Furthermore, the DIM- and 4-(di(1H-indol-3-yl)methyl)phenol (DIM-Ph-4-OH)-treated larvae completed normal settlement when they were transferred to clean seawater after being exposed to those compounds for 24 h. DIM also showed comparable antifouling performance to the commercial antifouling biocide Sea-Nine 211 (TM) in the field test over a period of 5 months, which further confirmed that DIMs can be considered as promising candidates of environmentally friendly antifouling compounds.
SubtypeArticle
KeywordBiofouling Low-toxicity Antifouling Compounds Diindol-3-ylmethane Pseudovibrio
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s10126-015-9656-6
URL查看原文
Indexed BySCI
Language英语
WOS KeywordVIBRIO-PARAHAEMOLYTICUS ; INDOLE ALKALOIDS ; MARINE SPONGES ; BACTERIUM ; METABOLITES ; INHIBITION ; ATTACHMENT ; BARNACLE ; BRYOZOAN ; BIOFILMS
WOS SubjectBiotechnology & Applied Microbiology ; Marine & Freshwater Biology
WOS IDWOS:000359948100008
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.idsse.ac.cn/handle/183446/784
Collection深海科学研究部_深海生物学研究室_深海微生物活性物质研究组
Affiliation1.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Peoples R China
2.Hong Kong Univ Sci & Technol, Div Life Sci, Clear Water Bay, Hong Kong, Peoples R China
3.Hong Kong Univ Sci & Technol, Environm Sci Program, Sch Sci, Clear Water Bay, Hong Kong, Peoples R China
4.Shenzhen Univ, Coll Life Sci, Shenzhen 518060, Peoples R China
5.Chinese Acad Sci, Sanya Inst Deep Sea Sci & Engn, Sanya 572000, Peoples R China
6.Jinan Univ, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Kai-Ling,Xu, Ying,Lu, Liang,et al. Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds[J]. MARINE BIOTECHNOLOGY,2015,17(5):624-632.
APA Wang, Kai-Ling.,Xu, Ying.,Lu, Liang.,Li, Yongxin.,Han, Zhuang.,...&Qian, Pei-Yuan.(2015).Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds.MARINE BIOTECHNOLOGY,17(5),624-632.
MLA Wang, Kai-Ling,et al."Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds".MARINE BIOTECHNOLOGY 17.5(2015):624-632.
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