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Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
Mao, Jingxin1,2; Zhang, Qinghai1,3; Zhang, Haiyan4; Zheng, Ke5; Wang, Rui6; Wang, Guoze1,3
2020-05-15
Source PublicationFRONTIERS IN ENDOCRINOLOGY
ISSN1664-2392
Volume11Pages:12
AbstractPurpose: To explore the risk factors that may predict the lymph node metastasis potential of these lesions and new prevention strategies in papillary thyroid carcinoma patients. Materials and Methods: In total, 9,369 papillary thyroid carcinoma patients with 37.17% lymph node metastasis were analyzed (Revman 5.3 software) in this study. The PubMed and Embase databases were used for searching works systematically that were published through to January 22, 2020. Results: Several factors were related to the increased risk of lymph node metastasis in patients with papillary thyroid carcinoma: age <45 years (pooled OR = 1.52, 95% CI = 1.14-2.01, p <0.00001); gender = male (pooled OR = 1.68, 95% CI = 1.51-1.87, p <0.00001); multifocality (pooled OR = 2.05, 95% CI = 1.45-2.89, p <0.0001); tumor size >= 1.0 cm (pooled OR = 3.53, 95% CI = 2.62-4.76, p <0.00001); tumor location at the upper pole 1/3 (pooled OR =1.46, 95% CI = 1.04-2.04, p = 0.03); capsular invasion + (pooled OR = 3.48, 95% CI = 1.69-7.54, p = 0.002); and extrathyroidal extension + (pooled OR = 2.03, 95% CI= 1.78-2.31, p <0.00001). However, tumor bilaterality (pooled OR = 0.85, 95% CI = 0.54-1.34, p = 0.49) and Hashimoto's thyroditis (pooled OR = 1.08, 95% CI = 0.79-1.49, p = 0.62) showed no correlation with lymph node metastasis in papillary thyroid carcinoma patients. Conclusion: The systematic review and meta-analysis defined several significant risk factors of lymph node metastasis in papillary thyroid cancer patients: age (<45 years), gender (male), multifocality, tumor size (>1 cm), tumor location (1/3 upper), capsular invasion, and extra thyroidal extension. Bilateral tumors and Hashimoto's thyroiditis were unrelated to lymph node metastasis in patients with papillary thyroid cancer.
Keywordpapillary thyroid carcinoma (PTC) lymph node metastasis (LNM) risk factor prognostic factor meta-analysis
DOI10.3389/fendo.2020.00265
Indexed BySCI ; SCI
Funding Organizationfirst-class discipline construction project in Guizhou Province-Public Health and Preventive Medicine ; Science and Technology Support Program Project of Guizhou Province, China
Language英语
Funding Projectfirst-class discipline construction project in Guizhou Province-Public Health and Preventive Medicine[2017 [85]] ; Science and Technology Support Program Project of Guizhou Province, China[2044] ; Science and Technology Support Program Project of Guizhou Province, China[2860] ; Science and Technology Support Program Project of Guizhou Province, China[2349]
WOS KeywordFINE-NEEDLE-ASPIRATION ; PREDICTIVE FACTORS ; EXTRATHYROIDAL EXTENSION ; TUMOR MULTIFOCALITY ; CANCER ; MICROCARCINOMA ; RECURRENCE ; IMPACT ; SURVEILLANCE ; DISSECTION
WOS Research AreaEndocrinology & Metabolism
WOS SubjectEndocrinology & Metabolism
WOS IDWOS:000538534800001
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.idsse.ac.cn/handle/183446/7702
Collection深海科学研究部_深海极端环境模拟研究实验室
Corresponding AuthorWang, Guoze
Affiliation1.Guizhou Med Univ, Minist Educ, Key Lab Environm Pollut Monitoring & Dis Control, Sch Publ Hlth, Guiyang, Peoples R China
2.Southwest Univ, Coll Pharmaceut Sci, Chongqing, Peoples R China
3.Guizhou Med Univ, Coll Food Sci, Guiyang, Peoples R China
4.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Sanya, Peoples R China
5.Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrine & Breast Surg, Chongqing, Peoples R China
6.Guilin Med Univ, Coll Pharm, Dept Pharmacol, Guilin, Peoples R China
Recommended Citation
GB/T 7714
Mao, Jingxin,Zhang, Qinghai,Zhang, Haiyan,et al. Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis[J]. FRONTIERS IN ENDOCRINOLOGY,2020,11:12.
APA Mao, Jingxin,Zhang, Qinghai,Zhang, Haiyan,Zheng, Ke,Wang, Rui,&Wang, Guoze.(2020).Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.FRONTIERS IN ENDOCRINOLOGY,11,12.
MLA Mao, Jingxin,et al."Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis".FRONTIERS IN ENDOCRINOLOGY 11(2020):12.
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