Unique tRNA gene profile suggests paucity of nucleotide modifications in anticodons of a deep-sea symbiotic Spiroplasma
Wang, Yong1; Zhu, Fang-Chao1; He, Li-Sheng1; Danchin, Antoine2,3; Wang, Yong(Chinese Acad Sci, Inst Deep Sea Sci & Engn, Sanya, Hainan, Peoples R China); Danchin, Antoine(Hop La Pitie Salpetriere, Inst Cardiometab & Nutr, 47 Blvd Hop, F-75013 Paris, France)
2018-03-16
Source PublicationNUCLEIC ACIDS RESEARCH
Volume46Issue:5Pages:2197-2203
Contribution Rank第1完成单位 ; 第2完成单位 ; 第3完成单位
AbstractThe position 34 of a tRNA is always modified for efficient recognition of codons and accurate integration of amino acids by the translation machinery. Here, we report genomics features of a deep-sea gut symbiotic Spiroplasma, which suggests that the organism does not require tRNA(34) anticodon modifications. In the genome, there is a novel set of tRNA genes composed of 32 species for recognition of the 20 amino acids. Among the anticodons of the tRNAs, we witnessed the presence of both U34- and C34 containing tRNAs required to decode NNR (A/G) 2:2 codons as countermeasure of probable loss of anticodon modification genes. In the tRNA fragments detected in the gut transcriptome, mismatches expected to be caused by some tRNA modifications were not shown in their alignments with the corresponding genes. However, the probable paucity of modified anticodons did not fundamentally change the codon usage pattern of the Spiroplasma. The tRNA gene profile that probably resulted from the paucity of tRNA(34) modifications was not observed in other symbionts and deep-sea bacteria, indicating that this phenomenon was an evolutionary deadend. This study provides insights on co-evolution of translation machine and tRNA genes and steric constraints of codon-anticodon interactions in deep-sea extreme environment.
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1093/narlgkx045
Indexed BySCI
Language英语
WOS KeywordSYNONYMOUS CODON USAGE ; ESCHERICHIA-COLI ; RIBOSOME ; CONSEQUENCES ; TRANSLATION ; MYCOPLASMAS ; SPECIFICITY ; ADAPTATION ; EVOLUTION ; SELECTION
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000427677100011
Citation statistics
Document Type期刊论文
Identifierhttp://ir.idsse.ac.cn/handle/183446/5927
Collection深海科学研究部_深海生物学研究室_海洋微生物宏基因组与分子进化研究组
Corresponding AuthorWang, Yong; Danchin, Antoine; Wang, Yong(Chinese Acad Sci, Inst Deep Sea Sci & Engn, Sanya, Hainan, Peoples R China); Danchin, Antoine(Hop La Pitie Salpetriere, Inst Cardiometab & Nutr, 47 Blvd Hop, F-75013 Paris, France)
Affiliation1.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Sanya, Hainan, Peoples R China
2.Hop La Pitie Salpetriere, Inst Cardiometab & Nutr, 47 Blvd Hop, F-75013 Paris, France
3.Univ Hong Kong, Sch Biomed Sci, Li Kashing Fac Med, 21 Sassoon Rd, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yong,Zhu, Fang-Chao,He, Li-Sheng,et al. Unique tRNA gene profile suggests paucity of nucleotide modifications in anticodons of a deep-sea symbiotic Spiroplasma[J]. NUCLEIC ACIDS RESEARCH,2018,46(5):2197-2203.
APA Wang, Yong,Zhu, Fang-Chao,He, Li-Sheng,Danchin, Antoine,Wang, Yong,&Danchin, Antoine.(2018).Unique tRNA gene profile suggests paucity of nucleotide modifications in anticodons of a deep-sea symbiotic Spiroplasma.NUCLEIC ACIDS RESEARCH,46(5),2197-2203.
MLA Wang, Yong,et al."Unique tRNA gene profile suggests paucity of nucleotide modifications in anticodons of a deep-sea symbiotic Spiroplasma".NUCLEIC ACIDS RESEARCH 46.5(2018):2197-2203.
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