The Enigmatic Genome of an Obligate Ancient Spiroplasma Symbiont in a Hadal Holothurian
He, Li-Sheng1; Zhang, Pei-Wei1; Huang, Jiao-Mei1; Zhu, Fang-Chao1; Danchin, Antoine2; Wang, Yong1; Danchin, Antoine(Hop La Pitie Salpetriere, Inst Cardiometab & Nutr, Paris, France); Wang, Yong(Chinese Acad Sci, Inst Deep Sea Sci & Engn, Sanya, Hainan, Peoples R China)
2018
Source PublicationAPPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume84Issue:1
Contribution Rank第1完成单位 ; 第2完成单位
AbstractProtective symbiosis has been reported in many organisms, but the molecular mechanisms of the mutualistic interactions between the symbionts and their hosts are unclear. Here, we sequenced the 424-kbp genome of "Candidatus Spiroplasma holothuricola," which dominated the hindgut microbiome of a sea cucumber, a major scavenger captured in the Mariana Trench (6,140 m depth). Phylogenetic relationships indicated that the dominant bacterium in the hindgut was derived from a basal group of Spiroplasma species. In this organism, the genes responsible for the biosynthesis of amino acids, glycolysis, and sugar transporters were lost, strongly suggesting endosymbiosis. The highly decayed genome consists of two chromosomes and harbors genes coding for proteolysis, microbial toxin, restrictionmethylation systems, and clustered regularly interspaced short palindromic repeats (CRISPRs), composed of three cas genes and 76 CRISPR spacers. The holothurian host is probably protected against invading viruses from sediments by the CRISPRs/Cas and restriction systems of the endosymbiotic spiroplasma. The protective endosymbiosis indicates the important ecological role of the ancient Spiroplasma symbiont in the maintenance of hadal ecosystems.
SubtypeArticle
KeywordSymbiosis Hadal Crispr Genome Reduction Spiroplasma
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1128/AEM.01965-17
URL查看原文
Indexed BySCI
Language英语
WOS KeywordPSEUDOMONAS-AERUGINOSA ; MODIFICATION SYSTEMS ; INSECT ENDOSYMBIONT ; GUT MICROBIOTA ; SEQUENCE ; BACTERIA ; METAGENOMES ; WOLBACHIA ; EVOLUTION ; ARGININE
WOS SubjectBiotechnology & Applied Microbiology ; Microbiology
WOS IDWOS:000418039700026
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.idsse.ac.cn/handle/183446/5203
Collection深海科学研究部_深海生物学研究室_深海无脊椎动物蛋白质组学及分子生物学研究组
深海科学研究部_深海生物学研究室
Corresponding AuthorDanchin, Antoine; Wang, Yong; Danchin, Antoine(Hop La Pitie Salpetriere, Inst Cardiometab & Nutr, Paris, France); Wang, Yong(Chinese Acad Sci, Inst Deep Sea Sci & Engn, Sanya, Hainan, Peoples R China)
Affiliation1.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Sanya, Hainan, Peoples R China
2.Hop La Pitie Salpetriere, Inst Cardiometab & Nutr, Paris, France
Recommended Citation
GB/T 7714
He, Li-Sheng,Zhang, Pei-Wei,Huang, Jiao-Mei,et al. The Enigmatic Genome of an Obligate Ancient Spiroplasma Symbiont in a Hadal Holothurian[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2018,84(1).
APA He, Li-Sheng.,Zhang, Pei-Wei.,Huang, Jiao-Mei.,Zhu, Fang-Chao.,Danchin, Antoine.,...&Wang, Yong.(2018).The Enigmatic Genome of an Obligate Ancient Spiroplasma Symbiont in a Hadal Holothurian.APPLIED AND ENVIRONMENTAL MICROBIOLOGY,84(1).
MLA He, Li-Sheng,et al."The Enigmatic Genome of an Obligate Ancient Spiroplasma Symbiont in a Hadal Holothurian".APPLIED AND ENVIRONMENTAL MICROBIOLOGY 84.1(2018).
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