Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha
Gao, X. G.1; Han, J. B.1; Lu, Z. C.1; Zhang, P. J.1,2; He, C. B.1
2015
发表期刊GENETICS AND MOLECULAR RESEARCH
卷号14期号:1页码:2055-2062
摘要The major histocompatibility complex (MHC) is one of the most important genetic systems associated with resistance to infectious diseases in vertebrates. The spotted seal (Phoca largha) is one of the most endangered species in China. In this study, we present the first step in the molecular characterization of a DRB-like locus in the spotted seal by analyzing the nucleotide sequence of the polymorphic exon 2 segments, a 288-nucleotide sequence. By examining the segment from a group of 41 individuals, 28 alleles were identified. No deletion, insertion, or exceptional stop codon was detected, suggesting that these alleles could be functional in vivo. The nucleotide and amino acid sequences of the segment both showed a relatively high level of similarity (nucleotides 97%; amino acids 98%) to those of Meles meles and Zalophus californianus. The high level of spotted seal MHC-DRB polymorphism revealed in the present study has not been reported for the Phocidae and could be a consequence of the small spotted seal population adapting to the Bohai Sea, which probably has a relatively high level of pathogens.
文章类型Article
关键词Spotted Seal (Phoca Largha) Sequence Variation Mhc Drb Gene Duplication
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.4238/2015.March.20.15
收录类别SCI
语种英语
关键词[WOS]EVOLUTION ; SELECTION ; INSIGHT
WOS类目Biochemistry & Molecular Biology ; Genetics & Heredity
WOS记录号WOS:000357192700055
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.idsse.ac.cn/handle/183446/507
专题深海科学研究部_深海生物学研究室_海洋哺乳动物与海洋生物声学研究组
作者单位1.Liaoning Ocean & Fisheries Sci Res Inst, Dalian, Peoples R China
2.Chinese Acad Sci, Sanya Inst Deep Sea Sci & Engn, Marine Mammal & Marine Bioacoust Lab, Sanya, Peoples R China
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Gao, X. G.,Han, J. B.,Lu, Z. C.,et al. Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(1):2055-2062.
APA Gao, X. G.,Han, J. B.,Lu, Z. C.,Zhang, P. J.,&He, C. B..(2015).Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha.GENETICS AND MOLECULAR RESEARCH,14(1),2055-2062.
MLA Gao, X. G.,et al."Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha".GENETICS AND MOLECULAR RESEARCH 14.1(2015):2055-2062.
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