Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha
Gao, X. G.1; Han, J. B.1; Lu, Z. C.1; Zhang, P. J.1,2; He, C. B.1
2015
Source PublicationGENETICS AND MOLECULAR RESEARCH
Volume14Issue:1Pages:2055-2062
AbstractThe major histocompatibility complex (MHC) is one of the most important genetic systems associated with resistance to infectious diseases in vertebrates. The spotted seal (Phoca largha) is one of the most endangered species in China. In this study, we present the first step in the molecular characterization of a DRB-like locus in the spotted seal by analyzing the nucleotide sequence of the polymorphic exon 2 segments, a 288-nucleotide sequence. By examining the segment from a group of 41 individuals, 28 alleles were identified. No deletion, insertion, or exceptional stop codon was detected, suggesting that these alleles could be functional in vivo. The nucleotide and amino acid sequences of the segment both showed a relatively high level of similarity (nucleotides 97%; amino acids 98%) to those of Meles meles and Zalophus californianus. The high level of spotted seal MHC-DRB polymorphism revealed in the present study has not been reported for the Phocidae and could be a consequence of the small spotted seal population adapting to the Bohai Sea, which probably has a relatively high level of pathogens.
SubtypeArticle
KeywordSpotted Seal (Phoca Largha) Sequence Variation Mhc Drb Gene Duplication
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.4238/2015.March.20.15
Indexed BySCI
Language英语
WOS KeywordEVOLUTION ; SELECTION ; INSIGHT
WOS SubjectBiochemistry & Molecular Biology ; Genetics & Heredity
WOS IDWOS:000357192700055
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.idsse.ac.cn/handle/183446/507
Collection深海科学研究部_深海生物学研究室_海洋哺乳动物与海洋生物声学研究组
Affiliation1.Liaoning Ocean & Fisheries Sci Res Inst, Dalian, Peoples R China
2.Chinese Acad Sci, Sanya Inst Deep Sea Sci & Engn, Marine Mammal & Marine Bioacoust Lab, Sanya, Peoples R China
Recommended Citation
GB/T 7714
Gao, X. G.,Han, J. B.,Lu, Z. C.,et al. Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(1):2055-2062.
APA Gao, X. G.,Han, J. B.,Lu, Z. C.,Zhang, P. J.,&He, C. B..(2015).Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha.GENETICS AND MOLECULAR RESEARCH,14(1),2055-2062.
MLA Gao, X. G.,et al."Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha".GENETICS AND MOLECULAR RESEARCH 14.1(2015):2055-2062.
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