Effects of intermediate metabolite carboxylic acids of TCA cycle on Microcystis with overproduction of phycocyanin
Bai, Shijie1,2,4,5; Dai, Jingcheng1,2,3; Xia, Ming1,2; Ruan, Jing1,2; Wei, Hehong1,2; Yu, Dianzhen1,2; Li, Ronghui1,2; Jing, Hongmei4,5; Tian, Chunyuan3; Song, Lirong1,2; Qiu, Dongru1,2
2015-04-01
Source PublicationENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
Volume22Issue:7Pages:5531-5537
AbstractToxic Microcystis species are the main bloom-forming cyanobacteria in freshwaters. It is imperative to develop efficient techniques to control these notorious harmful algal blooms (HABs). Here, we present a simple, efficient, and environmentally safe algicidal way to control Microcystis blooms, by using intermediate carboxylic acids from the tricarboxylic acid (TCA) cycle. The citric acid, alpha-ketoglutaric acid, succinic acid, fumaric acid, and malic acid all exhibited strong algicidal effects, and particularly succinic acid could cause the rapid lysis of Microcystis in a few hours. It is revealed that the Microcystis-lysing activity of succinic acid and other carboxylic acids was due to their strong acidic activity. Interestingly, the acid-lysed Microcystis cells released large amounts of phycocyanin, about 27-fold higher than those of the control. On the other hand, the transcription of mcyA and mcyD of the microcystin biosynthesis operon was not upregulated by addition of alpha-ketoglutaric acid and other carboxylic acids. Consider the environmental safety of intermediate carboxylic acids. We propose that administration of TCA cycle organic acids may not only provide an algicidal method with high efficiency and environmental safety but also serve as an applicable way to produce and extract phycocyanin from cyanobacterial biomass.
SubtypeArticle
KeywordMicrocystis Blooms Carboxylic Acids Phycocyanin High Efficiency Environmental Safety
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11356-014-3730-x
URL查看原文
Indexed BySCI
Language英语
WOS KeywordC-PHYCOCYANIN ; SPIRULINA-PLATENSIS ; FRESH-WATER ; PURIFICATION ; MARINE ; BLOOMS ; AERUGINOSA ; BIOMASS ; NTCA ; CYANOBACTERIA
WOS SubjectEnvironmental Sciences
WOS IDWOS:000351586500068
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Document Type期刊论文
Version出版稿
Identifierhttp://ir.idsse.ac.cn/handle/183446/466
Collection深海科学研究部_深海生物学研究室_海洋病毒与分子生物学研究组
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Wuhan 430072, Peoples R China
3.Hubei Univ Engn, Sch Life Sci & Technol, Xiaogan 432000, Peoples R China
4.Chinese Acad Sci, Sanya Inst Deep Sea Sci & Engn, Sanya 572000, Peoples R China
5.Univ Chinese Acad Sci, Sanya 572000, Peoples R China
First Author AffilicationInstitute of Deep-sea Science and Engineering,CAS
Recommended Citation
GB/T 7714
Bai, Shijie,Dai, Jingcheng,Xia, Ming,et al. Effects of intermediate metabolite carboxylic acids of TCA cycle on Microcystis with overproduction of phycocyanin[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2015,22(7):5531-5537.
APA Bai, Shijie.,Dai, Jingcheng.,Xia, Ming.,Ruan, Jing.,Wei, Hehong.,...&Qiu, Dongru.(2015).Effects of intermediate metabolite carboxylic acids of TCA cycle on Microcystis with overproduction of phycocyanin.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,22(7),5531-5537.
MLA Bai, Shijie,et al."Effects of intermediate metabolite carboxylic acids of TCA cycle on Microcystis with overproduction of phycocyanin".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 22.7(2015):5531-5537.
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