Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway
Wang, Kai-Ling1,2,5; Zhang, Gen3; Sun, Jin4; Xu, Ying2,5; Han, Zhuang5,6; Liu, Ling-Li3; Shao, Chang-Lun1; Liu, Qing-Ai1; Wang, Chang-Yun1; Qian, Pei-Yuan3,5
2016
Source PublicationBIOFOULING
Volume32Issue:1Pages:35-44
AbstractCochliomycin A is a compound with anti-barnacle settlement activity and low toxicity, but the molecular mechanism of the compound is unknown. Here, isobaric tags for the relative or absolute quantitation (iTRAQ) labeling proteomic method were applied to analyze changes in the proteome of Amphibalanus ( =Balanus) amphitrite cyprids in response to cochliomycin A treatment. Cochliomycin A affected the cytochrome P450, glutathione S-transferase (GST) and NO/cGMP pathways, among which the NO/cGMP pathway was considered to play a key role in barnacle larval settlement, while the cytochrome P450 and the GST pathways are mainly for detoxification. The results of real-time PCR further suggested the NO/cGMP pathway was activated in response to cochliomycin A. Larval settlement assays revealed that S-methylisothiourea sulfate (SMIS) and 1H-(1,2,4) oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) rescued cyprids from cochliomycin A-induced inhibition of larval settlement. The findings supported the hypothesis that cochliomycin A inhibited barnacle larval settlement by stimulating the NO/cGMP pathway.
SubtypeArticle
KeywordCochliomycin a Antifouling Barnacle Nitric Oxide Cgmp Mechanism
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1080/08927014.2015.1121245
URL查看原文
Indexed BySCI
Language英语
WOS KeywordNITRIC-OXIDE ; ANTIFOULING COMPOUNDS ; BALANUS-AMPHITRITE ; METAMORPHOSIS ; HSP90 ; BUTENOLIDE ; MECHANISMS ; ATTACHMENT ; EXPRESSION ; SYSTEM
WOS SubjectBiotechnology & Applied Microbiology ; Marine & Freshwater Biology
WOS IDWOS:000368561300005
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.idsse.ac.cn/handle/183446/1346
Collection深海科学研究部_深海生物学研究室_深海微生物活性物质研究组
Affiliation1.Ocean Univ China, Key Lab Marine Drugs, Minist Educ China, Sch Med & Pharm, Qingdao, Peoples R China
2.Shenzhen Univ, Coll Life Sci, Shenzhen, Peoples R China
3.Hong Kong Univ Sci & Technol, Sch Sci, Environm Sci Program, Hong Kong, Hong Kong, Peoples R China
4.Hong Kong Baptist Univ, Dept Biol, Hong Kong, Hong Kong, Peoples R China
5.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
6.Chinese Acad Sci, Sanya Inst Deep Sea Sci & Engn, Sanya, Peoples R China
Recommended Citation
GB/T 7714
Wang, Kai-Ling,Zhang, Gen,Sun, Jin,et al. Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway[J]. BIOFOULING,2016,32(1):35-44.
APA Wang, Kai-Ling.,Zhang, Gen.,Sun, Jin.,Xu, Ying.,Han, Zhuang.,...&Qian, Pei-Yuan.(2016).Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway.BIOFOULING,32(1),35-44.
MLA Wang, Kai-Ling,et al."Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway".BIOFOULING 32.1(2016):35-44.
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