Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway
Wang, Kai-Ling1,2,5; Zhang, Gen3; Sun, Jin4; Xu, Ying2,5; Han, Zhuang5,6; Liu, Ling-Li3; Shao, Chang-Lun1; Liu, Qing-Ai1; Wang, Chang-Yun1; Qian, Pei-Yuan3,5
2016
发表期刊BIOFOULING
卷号32期号:1页码:35-44
摘要Cochliomycin A is a compound with anti-barnacle settlement activity and low toxicity, but the molecular mechanism of the compound is unknown. Here, isobaric tags for the relative or absolute quantitation (iTRAQ) labeling proteomic method were applied to analyze changes in the proteome of Amphibalanus ( =Balanus) amphitrite cyprids in response to cochliomycin A treatment. Cochliomycin A affected the cytochrome P450, glutathione S-transferase (GST) and NO/cGMP pathways, among which the NO/cGMP pathway was considered to play a key role in barnacle larval settlement, while the cytochrome P450 and the GST pathways are mainly for detoxification. The results of real-time PCR further suggested the NO/cGMP pathway was activated in response to cochliomycin A. Larval settlement assays revealed that S-methylisothiourea sulfate (SMIS) and 1H-(1,2,4) oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) rescued cyprids from cochliomycin A-induced inhibition of larval settlement. The findings supported the hypothesis that cochliomycin A inhibited barnacle larval settlement by stimulating the NO/cGMP pathway.
文章类型Article
关键词Cochliomycin a Antifouling Barnacle Nitric Oxide Cgmp Mechanism
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1080/08927014.2015.1121245
URL查看原文
收录类别SCI
语种英语
关键词[WOS]NITRIC-OXIDE ; ANTIFOULING COMPOUNDS ; BALANUS-AMPHITRITE ; METAMORPHOSIS ; HSP90 ; BUTENOLIDE ; MECHANISMS ; ATTACHMENT ; EXPRESSION ; SYSTEM
WOS类目Biotechnology & Applied Microbiology ; Marine & Freshwater Biology
WOS记录号WOS:000368561300005
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.idsse.ac.cn/handle/183446/1346
专题深海科学研究部_深海生物学研究室_深海微生物活性物质研究组
作者单位1.Ocean Univ China, Key Lab Marine Drugs, Minist Educ China, Sch Med & Pharm, Qingdao, Peoples R China
2.Shenzhen Univ, Coll Life Sci, Shenzhen, Peoples R China
3.Hong Kong Univ Sci & Technol, Sch Sci, Environm Sci Program, Hong Kong, Hong Kong, Peoples R China
4.Hong Kong Baptist Univ, Dept Biol, Hong Kong, Hong Kong, Peoples R China
5.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
6.Chinese Acad Sci, Sanya Inst Deep Sea Sci & Engn, Sanya, Peoples R China
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Wang, Kai-Ling,Zhang, Gen,Sun, Jin,et al. Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway[J]. BIOFOULING,2016,32(1):35-44.
APA Wang, Kai-Ling.,Zhang, Gen.,Sun, Jin.,Xu, Ying.,Han, Zhuang.,...&Qian, Pei-Yuan.(2016).Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway.BIOFOULING,32(1),35-44.
MLA Wang, Kai-Ling,et al."Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway".BIOFOULING 32.1(2016):35-44.
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